Effect of Intravenous Dexmedetomidine on Spinal Anaesthesia with Hyperbaric Bupivacine

• Main Authors: Shambhu Prasad Sharma, Raghu K, Sudarshan Naik
• Format: Article
• Language: English
• Published: Krishna Institute of Medical Sciences University 2020-01-01
• Series: Journal of Krishna Institute of Medical Sciences University
• Subjects: spinal anaesthesia; bupivacaine; dexmedetomidine
• Online Access: https://www.jkimsu.com/jkimsu-vol9no1/JKIMSU,%20Vol.%209,%20No.%201,%20January-March%202020%20Page%2036-42.pdf
• ISSN: 2231-4261; 2231-4261

Background: Spinal anaesthesia is one of the commonest anaesthetic techniques for infra-umbilical surgeries. Administration of dexmedetomidine for sedation during spinal anaesthesia is found to prolong the duration of block. Aim and Objectives: To evaluating the effect of intravenous dexmedetomidine on block characteristic of spinal anaesthesia with hyperbaric bupivacaine. Material and Methods: A total of 120 patients scheduled for various elective surgeries under spinal anaesthesia with hyperbaric bupivacaine were included in the study. The patients were divided into two groups of each containing 60 subjects. Group D received 1μg/kg bolus dexmedetomidine over 10 minutes immediately after spinal anaesthesia followed by 0.5μg/kg/hr infusion till the end of surgery and Group S received similar amount of saline. Data collected include onset of sensory and motor blockade, time for two segmental regression of block, duration of analgesia and sedation score were noted. Results: Onset of sensory block was faster in group D (2.38±1.48 min) as compared to Group S (3.03±0.22 min). Onset of motor block was significantly faster in Group D (6.97±0.93 min) as compared to Group S (8.01±0.85 min). Time required for two segment regression was prolonged in Group D (122.67±7.15 min) as compared to Group S (65.76±4.71 min). Total duration of analgesia was also prolonged in group D (4.29 ±1.04 hr) compared to Group S (2.24±0.29 hr). Conclusion: Intravenous administration of dexmedetomidine prolongs the duration of sensory and motor blockade with arousable sedation.