Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes
This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as wel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/18/6/6804 |
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doaj-418512882d9f4e218025ada5ebdf51ee2020-11-24T23:40:42ZengMDPI AGMolecules1420-30492013-06-011866804682810.3390/molecules18066804Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich ComplexesPetr KačerMarek KuzmaJan PecháčekPetr ŠotBeáta VilhanováJiří VáclavíkThis review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included.http://www.mdpi.com/1420-3049/18/6/6804asymmetric hydrogenationrutheniumreaction conditionsmechanismimine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Petr Kačer Marek Kuzma Jan Pecháček Petr Šot Beáta Vilhanová Jiří Václavík |
| spellingShingle |
Petr Kačer Marek Kuzma Jan Pecháček Petr Šot Beáta Vilhanová Jiří Václavík Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes Molecules asymmetric hydrogenation ruthenium reaction conditions mechanism imine |
| author_facet |
Petr Kačer Marek Kuzma Jan Pecháček Petr Šot Beáta Vilhanová Jiří Václavík |
| author_sort |
Petr Kačer |
| title |
Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes |
| title_short |
Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes |
| title_full |
Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes |
| title_fullStr |
Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes |
| title_full_unstemmed |
Practical Aspects and Mechanism of Asymmetric Hydrogenation with Chiral Half-Sandwich Complexes |
| title_sort |
practical aspects and mechanism of asymmetric hydrogenation with chiral half-sandwich complexes |
| publisher |
MDPI AG |
| series |
Molecules |
| issn |
1420-3049 |
| publishDate |
2013-06-01 |
| description |
This review is oriented toward the asymmetric transfer hydrogenation (ATH) of imines regarding mostly fundamental, yet important topics from the practical point of view. Development of analytical methods for the monitoring of ATH (i.e., kinetics and stereoselectivity) belongs to those topics, as well as studies on the influence of reaction conditions and structural variations on the reaction performance. The second part is devoted to the reaction mechanism with the emphasis on imine ATH and catalyst behaviour under acidic conditions. The review also addresses the asymmetric hydrogenation (AH) of ketones and imines using molecular hydrogen and the application of ATH in pharmaceutical projects. The contributions of our group to each area are included. |
| topic |
asymmetric hydrogenation ruthenium reaction conditions mechanism imine |
| url |
http://www.mdpi.com/1420-3049/18/6/6804 |
| work_keys_str_mv |
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