Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

Glioma-associated microglia/macrophages display an expression profile different from M1 and M2 polarization and highly express Gpnmb and Spp1.

Malignant glioma belong to the most aggressive neoplasms in humans with no successful treatment available. Patients suffering from glioblastoma multiforme (GBM), the highest-grade glioma, have an average survival time of only around one year after diagnosis. Both microglia and peripheral macrophages...

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Bibliographic Details
Main Authors: Frank Szulzewsky, Andreas Pelz, Xi Feng, Michael Synowitz, Darko Markovic, Thomas Langmann, Inge R Holtman, Xi Wang, Bart J L Eggen, Hendrikus W G M Boddeke, Dolores Hambardzumyan, Susanne A Wolf, Helmut Kettenmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4320099?pdf=render

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http://europepmc.org/articles/PMC4320099?pdf=render

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