Synergistic Anti-Angiogenic Effects Using Peptide-Based Combinatorial Delivery of siRNAs Targeting VEGFA, VEGFR1, and Endoglin Genes

Synergistic Anti-Angiogenic Effects Using Peptide-Based Combinatorial Delivery of siRNAs Targeting VEGFA, VEGFR1, and Endoglin Genes

Angiogenesis is a process of new blood vessel formation, which plays a significant role in carcinogenesis and the development of diseases associated with pathological neovascularization. An important role in the regulation of angiogenesis belongs to several key pathways such as VEGF-pathways, TGF-&a...

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Bibliographic Details
Main Authors: Anna A. Egorova, Sofia V. Shtykalova, Marianna A. Maretina, Dmitry I. Sokolov, Sergei A. Selkov, Vladislav S. Baranov, Anton V. Kiselev
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Pharmaceutics
Subjects:
VEGFA
VEGFR1
endoglin
siRNA delivery
peptide
angiogenesis
gene silencing
migration
proliferation
endothelial cells
Online Access:https://www.mdpi.com/1999-4923/11/6/261

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