| Summary: | Objective: To study the correlation of the quantitative ultrasonography parameters with
liver cancer cell proliferation activity and intralesional angiogenesis. Methods: A total of
46 patients with liver cancer who received surgical resection in Hancheng People’s Hospital
between June 2014 and March 2017 as well as 28 patients who received partial hepatectomy
for abdominal trauma during the same period were selected, the patients with liver cancer
received ultrasonography, and the quantitative parameters were calculated; the liver cancer
tissue and adjacent tissue of patients with liver cancer as well as the normal liver tissue of
patients with abdominal trauma were collected to determine the expression of proliferation
genes, tumor suppressor genes and angiogenesis genes. Results: The IMAX of liver cancer
tissue was significantly higher than that of adjacent tissue while the TTP, WT and mTT were
significantly shorter than those of adjacent tissue; RNF180, Merlin, PICK1 and PTEN protein
expression in liver cancer tissue and adjacent tissue were significantly lower than those in
normal liver tissue, negatively correlated with the IMAX of liver cancer tissue, and positively
correlated with the TTP, WT and mTT of liver cancer tissue; EphB4, SALL4, Cripto-1, VEGF,
PDGF, EGFR and Ang-2 protein expression in liver cancer tissue and adjacent tissue were
significantly higher than those in normal liver tissue, positively correlated with the IMAX of
liver cancer tissue, and negatively correlated with the TTP, WT and mTT of liver cancer tissue.
Conclusion: The changes in the quantitative parameters of liver cancer ultrasonography are
valuable for evaluating the cell proliferation and angiogenesis.
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