Dual Loss of Rb1 and Trp53 in the Adrenal Medulla Leads to Spontaneous Pheochromocytoma

Dual Loss of Rb1 and Trp53 in the Adrenal Medulla Leads to Spontaneous Pheochromocytoma

Using a Cre/loxP system, we have determined the phenotypic consequences attributable to in vivo deletion of both Rb1 and Trp53 in the mouse adrenal medulla. The coablation of these two tumor suppressor genes during embryogenesis did not disrupt adrenal gland development but resulted in the neoplast...

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Bibliographic Details
Main Authors: Ian D. Tonks, Arne W. Mould, Wayne A. Schroder, Andrew Cotterill, Nicholas K. Hayward, Graeme J. Walker, Graham F. Kay
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610801022

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