Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer

Objective: Conventional prognostic factors are not yet sufficient to predict treatment outcomes factors in nasopharyngeal carcinoma (NPC). Parameters from PET/CT are still being investigated as a prognostic factor in nasopharyngeal cancer. Materials and Methods: We retrospectively analyzed total les...

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Main Authors: Mete Gündoğ, Ummuhan Abdulrezzak
Format: Article
Language:English
Published: KARE Publishing 2020-11-01
Series:Erciyes Medical Journal
Subjects:
Online Access:https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-14564
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spelling doaj-416acaea26384723b69303dc89fe88342021-01-24T18:17:04ZengKARE PublishingErciyes Medical Journal2149-22472020-11-0142438639410.14744/etd.2020.14564EMJ-14564Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal CancerMete Gündoğ0Ummuhan Abdulrezzak1Department of Radiation Oncology, Erciyes University Faculty of Medicine, Kayseri, TurkeyDepartment of Nuclear Medicine, Erciyes University Faculty of Medicine, Kayseri, TurkeyObjective: Conventional prognostic factors are not yet sufficient to predict treatment outcomes factors in nasopharyngeal carcinoma (NPC). Parameters from PET/CT are still being investigated as a prognostic factor in nasopharyngeal cancer. Materials and Methods: We retrospectively analyzed total lesion glycolysis (TLG), metabolic tumor volume (MTV), and maximum standardized uptake value (SUVmax) in patients with non-metastatic nasopharyngeal cancer treated with intensity-adjusted radiotherapy. According to the ROC analysis, we divided the whole cohort into two groups. Kaplan-Meier tests were used to evaluate survival differences between groups. Univariate and multivariate analyzes were performed to find the factors affecting the prognosis. P<0.05 was accepted as statistically significant. Results: Ninety-one non-metastatic nasopharyngeal cancer patients were enrolled in this study. According to cut-off values, both MTVtumor and TLGnode were found as an independent prognostic factor for overall survival (OS). High MTVtumor (>21.5) and high TLGnode (>186.7) correlated with 4.9 and 4-fold increased mortality risk, respectively. Multivariate analyses showed high MTVtotal (>59.5) was associated with a 3.3 fold increased risk of locoregional recurrence. High TLGtotal (>181.56) was found to be independent prognostic factor for distant metastasis-free survival and it was associated with a 5.4 fold increased risk. The 5-years OS rate was 58.5% in high MTVtotal (>59.5) patients and 82.4% in low MTVtotal (<59.5) patients (p<0.01). The 5-years OS rates were 64.2% in patients with high TLGtotal (>181) and 88% in patients with low TLGtotal (p<0.01). Conclusion: The results of our study showed that MTVtumor and TLGnode values are significant independent prognostic factors for OS.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-14564metabolic tumor volumetotal lesion glycolysispet-derived parametersnasopharyngeal cancer
collection DOAJ
language English
format Article
sources DOAJ
author Mete Gündoğ
Ummuhan Abdulrezzak
spellingShingle Mete Gündoğ
Ummuhan Abdulrezzak
Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
Erciyes Medical Journal
metabolic tumor volume
total lesion glycolysis
pet-derived parameters
nasopharyngeal cancer
author_facet Mete Gündoğ
Ummuhan Abdulrezzak
author_sort Mete Gündoğ
title Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
title_short Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
title_full Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
title_fullStr Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
title_full_unstemmed Pretreatment Metabolic Tumor Volume of Primary Tumor and Total Lesion Glycolysis of Lymph Nodes are Predictive in Nasopharyngeal Cancer
title_sort pretreatment metabolic tumor volume of primary tumor and total lesion glycolysis of lymph nodes are predictive in nasopharyngeal cancer
publisher KARE Publishing
series Erciyes Medical Journal
issn 2149-2247
publishDate 2020-11-01
description Objective: Conventional prognostic factors are not yet sufficient to predict treatment outcomes factors in nasopharyngeal carcinoma (NPC). Parameters from PET/CT are still being investigated as a prognostic factor in nasopharyngeal cancer. Materials and Methods: We retrospectively analyzed total lesion glycolysis (TLG), metabolic tumor volume (MTV), and maximum standardized uptake value (SUVmax) in patients with non-metastatic nasopharyngeal cancer treated with intensity-adjusted radiotherapy. According to the ROC analysis, we divided the whole cohort into two groups. Kaplan-Meier tests were used to evaluate survival differences between groups. Univariate and multivariate analyzes were performed to find the factors affecting the prognosis. P<0.05 was accepted as statistically significant. Results: Ninety-one non-metastatic nasopharyngeal cancer patients were enrolled in this study. According to cut-off values, both MTVtumor and TLGnode were found as an independent prognostic factor for overall survival (OS). High MTVtumor (>21.5) and high TLGnode (>186.7) correlated with 4.9 and 4-fold increased mortality risk, respectively. Multivariate analyses showed high MTVtotal (>59.5) was associated with a 3.3 fold increased risk of locoregional recurrence. High TLGtotal (>181.56) was found to be independent prognostic factor for distant metastasis-free survival and it was associated with a 5.4 fold increased risk. The 5-years OS rate was 58.5% in high MTVtotal (>59.5) patients and 82.4% in low MTVtotal (<59.5) patients (p<0.01). The 5-years OS rates were 64.2% in patients with high TLGtotal (>181) and 88% in patients with low TLGtotal (p<0.01). Conclusion: The results of our study showed that MTVtumor and TLGnode values are significant independent prognostic factors for OS.
topic metabolic tumor volume
total lesion glycolysis
pet-derived parameters
nasopharyngeal cancer
url https://jag.journalagent.com/z4/download_fulltext.asp?pdir=erciyesmedj&un=EMJ-14564
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