Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits

Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits

The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and adrenaline on the CAVI in anesthetized rabbits. A h...

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Main Authors: Kiyoshi Sakuma, Akira Shimoda, Hiroaki Shiratori, Tetsuya Komatsu, Kento Watanabe, Tatsuo Chiba, Megumi Aimoto, Yoshinobu Nagasawa, Yuichi Hori, Kohji Shirai, Akira Takahara
Format: Article
Language:English
Published: Elsevier 2019-06-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319341696
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spelling doaj-414c82dda04a4e4db83558f16746122d2020-11-25T02:46:51ZengElsevierJournal of Pharmacological Sciences1347-86132019-06-011402205209Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbitsKiyoshi Sakuma0Akira Shimoda1Hiroaki Shiratori2Tetsuya Komatsu3Kento Watanabe4Tatsuo Chiba5Megumi Aimoto6Yoshinobu Nagasawa7Yuichi Hori8Kohji Shirai9Akira Takahara10Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, Japan; Department of Ophthalmology, Toho University Graduate School of Medicine, Ota-ku, Tokyo, 143-8541, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, Japan; Department of Ophthalmology, Toho University Graduate School of Medicine, Ota-ku, Tokyo, 143-8541, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, Japan; Department of Pharmacy, Toho University Omori Medical Center, Ota-ku, Tokyo, 143-8541, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, JapanDepartment of Ophthalmology, Toho University Graduate School of Medicine, Ota-ku, Tokyo, 143-8541, JapanMihama Hospital, Chiba, 261-0013, JapanDepartment of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, 274-8510, Japan; Corresponding author. Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan. Fax: +81 47 472 3225.The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and adrenaline on the CAVI in anesthetized rabbits. A hypertensive dose of angiotensin II (300 ng/kg, i.v.) increased the CAVI as well as the heart-ankle pulse wave velocity (haPWV). On the other hand, although a hypertensive dose of adrenaline (1000 ng/kg, i.v.) increased the haPWV, it did not affect the CAVI. These results suggest that angiotensin II may act as a regulatory factor for arterial stiffness. Keywords: Arterial stiffness, Angiotensin II, Adrenalinehttp://www.sciencedirect.com/science/article/pii/S1347861319341696
collection DOAJ
language English
format Article
sources DOAJ
author Kiyoshi Sakuma
Akira Shimoda
Hiroaki Shiratori
Tetsuya Komatsu
Kento Watanabe
Tatsuo Chiba
Megumi Aimoto
Yoshinobu Nagasawa
Yuichi Hori
Kohji Shirai
Akira Takahara
spellingShingle Kiyoshi Sakuma
Akira Shimoda
Hiroaki Shiratori
Tetsuya Komatsu
Kento Watanabe
Tatsuo Chiba
Megumi Aimoto
Yoshinobu Nagasawa
Yuichi Hori
Kohji Shirai
Akira Takahara
Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
Journal of Pharmacological Sciences
author_facet Kiyoshi Sakuma
Akira Shimoda
Hiroaki Shiratori
Tetsuya Komatsu
Kento Watanabe
Tatsuo Chiba
Megumi Aimoto
Yoshinobu Nagasawa
Yuichi Hori
Kohji Shirai
Akira Takahara
author_sort Kiyoshi Sakuma
title Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
title_short Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
title_full Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
title_fullStr Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
title_full_unstemmed Angiotensin II acutely increases arterial stiffness as monitored by cardio-ankle vascular index (CAVI) in anesthetized rabbits
title_sort angiotensin ii acutely increases arterial stiffness as monitored by cardio-ankle vascular index (cavi) in anesthetized rabbits
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2019-06-01
description The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and adrenaline on the CAVI in anesthetized rabbits. A hypertensive dose of angiotensin II (300 ng/kg, i.v.) increased the CAVI as well as the heart-ankle pulse wave velocity (haPWV). On the other hand, although a hypertensive dose of adrenaline (1000 ng/kg, i.v.) increased the haPWV, it did not affect the CAVI. These results suggest that angiotensin II may act as a regulatory factor for arterial stiffness. Keywords: Arterial stiffness, Angiotensin II, Adrenaline
url http://www.sciencedirect.com/science/article/pii/S1347861319341696
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