Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model.

Molecular constraints on synaptic tagging and maintenance of long-term potentiation: a predictive model.

Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity. Persistent increased activity of protein kinase M ζ (PKMζ) is thought essential for maintaining LTP. Additional...

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Bibliographic Details
Main Authors: Paul Smolen, Douglas A Baxter, John H Byrne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC3410876?pdf=render

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