Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs

Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ at...

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Main Author: Marc R. Hammerman
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Journal of Transplantation
Online Access:http://dx.doi.org/10.1155/2011/501749
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spelling doaj-413b5829a4b344919d889640361390222020-11-24T23:54:18ZengHindawi LimitedJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/501749501749Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature OrgansMarc R. Hammerman0Renal Division, Departments of Medicine and Cell Biology and Physiology, George M. O'Brien Center for Kidney Disease Research, Washington University School of Medicine P.O. Box 8126, St. Louis, MO 63110, USALack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression. However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia. Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy.http://dx.doi.org/10.1155/2011/501749
collection DOAJ
language English
format Article
sources DOAJ
author Marc R. Hammerman
spellingShingle Marc R. Hammerman
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Journal of Transplantation
author_facet Marc R. Hammerman
author_sort Marc R. Hammerman
title Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
title_short Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
title_full Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
title_fullStr Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
title_full_unstemmed Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
title_sort xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs
publisher Hindawi Limited
series Journal of Transplantation
issn 2090-0007
2090-0015
publishDate 2011-01-01
description Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression. However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia. Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy.
url http://dx.doi.org/10.1155/2011/501749
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