Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ at...
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2011-01-01
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Series: | Journal of Transplantation |
Online Access: | http://dx.doi.org/10.1155/2011/501749 |
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doaj-413b5829a4b344919d889640361390222020-11-24T23:54:18ZengHindawi LimitedJournal of Transplantation2090-00072090-00152011-01-01201110.1155/2011/501749501749Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature OrgansMarc R. Hammerman0Renal Division, Departments of Medicine and Cell Biology and Physiology, George M. O'Brien Center for Kidney Disease Research, Washington University School of Medicine P.O. Box 8126, St. Louis, MO 63110, USALack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression. However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia. Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy.http://dx.doi.org/10.1155/2011/501749 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marc R. Hammerman |
spellingShingle |
Marc R. Hammerman Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs Journal of Transplantation |
author_facet |
Marc R. Hammerman |
author_sort |
Marc R. Hammerman |
title |
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs |
title_short |
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs |
title_full |
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs |
title_fullStr |
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs |
title_full_unstemmed |
Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs |
title_sort |
xenotransplantation of embryonic pig kidney or pancreas to replace the function of mature organs |
publisher |
Hindawi Limited |
series |
Journal of Transplantation |
issn |
2090-0007 2090-0015 |
publishDate |
2011-01-01 |
description |
Lack of donor availability limits the number of human donor organs. The need for host immunosuppression complicates transplantation procedures. Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia. The developing organ attracts its blood supply from the host, obviating humoral rejection. Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression. However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques. Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia. Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy. |
url |
http://dx.doi.org/10.1155/2011/501749 |
work_keys_str_mv |
AT marcrhammerman xenotransplantationofembryonicpigkidneyorpancreastoreplacethefunctionofmatureorgans |
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