Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway

Caffeine prevents hyperoxia-induced lung injury in neonatal mice through NLRP3 inflammasome and NF-κB pathway

Abstract Background Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in premature infants and hyperoxia exposure is a major cause. In hyperoxic lung injury animal model, alveolar simplification and pro-inflammatory cells infiltration are the main pathophysiologic changes. Caffeine i...

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Bibliographic Details
Main Authors: Shangqin Chen, Qiuping Wu, Dingjuan Zhong, Changchong Li, Lizhong Du
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Respiratory Research
Subjects:
Bronchopulmonary dysplasia
Oxidative stress
Caffeine
Inflammasome
NF-κB pathway
Online Access:http://link.springer.com/article/10.1186/s12931-020-01403-2

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