Tissue-Specific GHR Knockout Mice: An Updated Review

• Main Authors: Akash Nagarajan, Hemant Srivastava, Joseph Jablonsky, Liou Y. Sun
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-10-01
• Series: Frontiers in Endocrinology
• Subjects: growth hormone; aging; longevity; mice; metabolism
• Online Access: https://www.frontiersin.org/article/10.3389/fendo.2020.579909/full

Growth hormone (GH) signaling plays a key role in mediating growth, development, metabolism, and lifespan regulation. However, the mechanisms of longevity regulation at the cellular and molecular level are still not well-understood. An important area in the field of GH research is in the development of advanced transgenic systems for conditional expression of GH signaling in a cell type- or tissue-specific manner. There have been many recent studies conducted to examine the effects of tissue-specific GHR disruption. This review updates our previous discussions on this topic and summarizes recent data on the newly-made tissue-specific GHR-KO mice including intestinal epithelial cells, bone, hematopoietic stem cells, cardiac myocytes, and specific brain regions. The data from these new genetically-engineered mice have a significant impact on our understanding of the local GH signaling function.