Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study

Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study

Carotenoid rich diets have proven to be beneficial in decreasing urinary symptoms of benign prostatic hyperplasia (BHP) and cardiovascular risk factors, especially following the consumption of whole tomato, the major source of dietary lycopene. Here, we describe the results of a phase II prospective...

Full description

Bibliographic Details
Main Authors: Eugenia Quiros-Roldan, MD, PhD, Canio Carriero, MD, Simone Paghera, BSc, Melania Degli Antoni, MD, Chiara Fiorini, BSc, Virginia Quaresima, PhD, Francesco Castelli, MD, Luisa Imberti, MD
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Journal of Functional Foods
Subjects:
HIV
Benign prostate hyperplasia
Lower urinary tract symptoms
Food supplement
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464621001444
id doaj-41342ea3e750451d8434ef6c730cfc97
record_format Article
spelling doaj-41342ea3e750451d8434ef6c730cfc972021-06-07T06:46:45ZengElsevierJournal of Functional Foods1756-46462021-07-0182104495Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled studyEugenia Quiros-Roldan, MD, PhD0Canio Carriero, MD1Simone Paghera, BSc2Melania Degli Antoni, MD3Chiara Fiorini, BSc4Virginia Quaresima, PhD5Francesco Castelli, MD6Luisa Imberti, MD7Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, ItalyDepartment of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, ItalyCentro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, ItalyDepartment of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, ItalyCentro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, ItalyCentro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, ItalyDepartment of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, ItalyCentro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Italy; Corresponding author at: Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Piazzale Spedali civili, 1 25123 Brescia, Italy.Carotenoid rich diets have proven to be beneficial in decreasing urinary symptoms of benign prostatic hyperplasia (BHP) and cardiovascular risk factors, especially following the consumption of whole tomato, the major source of dietary lycopene. Here, we describe the results of a phase II prospective, randomized double-blinded, placebo-controlled study undertaken to determine the efficacy and safety of a novel whole tomato-based food supplement (WTFS) containing lycopene in highly bioavailable form in 31 HIV+ patients with proved BPH. The consecutive enrolled patients received daily, for 12 weeks, 5 g of WTFS or placebo.The study demonstrates that WTFS consumption is associated with a statistically significant improvement of all BPH symptoms and quality of life, free/total prostate specific antigen ratio, and diastolic blood pressure, with a trend in interleukin 6 level reduction.WTFS may offer a side effect-free food supplement for the management of BPH in HIV+ patients.http://www.sciencedirect.com/science/article/pii/S1756464621001444HIVBenign prostate hyperplasiaLower urinary tract symptomsFood supplement
collection DOAJ
language English
format Article
sources DOAJ
author Eugenia Quiros-Roldan, MD, PhD
Canio Carriero, MD
Simone Paghera, BSc
Melania Degli Antoni, MD
Chiara Fiorini, BSc
Virginia Quaresima, PhD
Francesco Castelli, MD
Luisa Imberti, MD
spellingShingle Eugenia Quiros-Roldan, MD, PhD
Canio Carriero, MD
Simone Paghera, BSc
Melania Degli Antoni, MD
Chiara Fiorini, BSc
Virginia Quaresima, PhD
Francesco Castelli, MD
Luisa Imberti, MD
Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
Journal of Functional Foods
HIV
Benign prostate hyperplasia
Lower urinary tract symptoms
Food supplement
author_facet Eugenia Quiros-Roldan, MD, PhD
Canio Carriero, MD
Simone Paghera, BSc
Melania Degli Antoni, MD
Chiara Fiorini, BSc
Virginia Quaresima, PhD
Francesco Castelli, MD
Luisa Imberti, MD
author_sort Eugenia Quiros-Roldan, MD, PhD
title Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
title_short Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
title_full Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
title_fullStr Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
title_full_unstemmed Symptoms and quality of life in HIV-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. A phase II prospective, randomized double-blinded, placebo-controlled study
title_sort symptoms and quality of life in hiv-infected patients with benign prostatic hyperplasia are improved by the consumption of a newly developed whole tomato-based food supplement. a phase ii prospective, randomized double-blinded, placebo-controlled study
publisher Elsevier
series Journal of Functional Foods
issn 1756-4646
publishDate 2021-07-01
description Carotenoid rich diets have proven to be beneficial in decreasing urinary symptoms of benign prostatic hyperplasia (BHP) and cardiovascular risk factors, especially following the consumption of whole tomato, the major source of dietary lycopene. Here, we describe the results of a phase II prospective, randomized double-blinded, placebo-controlled study undertaken to determine the efficacy and safety of a novel whole tomato-based food supplement (WTFS) containing lycopene in highly bioavailable form in 31 HIV+ patients with proved BPH. The consecutive enrolled patients received daily, for 12 weeks, 5 g of WTFS or placebo.The study demonstrates that WTFS consumption is associated with a statistically significant improvement of all BPH symptoms and quality of life, free/total prostate specific antigen ratio, and diastolic blood pressure, with a trend in interleukin 6 level reduction.WTFS may offer a side effect-free food supplement for the management of BPH in HIV+ patients.
topic HIV
Benign prostate hyperplasia
Lower urinary tract symptoms
Food supplement
url http://www.sciencedirect.com/science/article/pii/S1756464621001444
work_keys_str_mv AT eugeniaquirosroldanmdphd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT caniocarrieromd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT simonepagherabsc symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT melaniadegliantonimd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT chiarafiorinibsc symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT virginiaquaresimaphd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT francescocastellimd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
AT luisaimbertimd symptomsandqualityoflifeinhivinfectedpatientswithbenignprostatichyperplasiaareimprovedbytheconsumptionofanewlydevelopedwholetomatobasedfoodsupplementaphaseiiprospectiverandomizeddoubleblindedplacebocontrolledstudy
_version_ 1721392728072257536

Similar Items