A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-Fluorouracil

A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-Fluorouracil

Borneol and menthol are terpenes that are widely used as penetration enhancers in transdermal drug delivery. To explore their penetration-enhancement effects on hydrophilic drugs, 5-fluorouracil (5-FU) was selected as a model drug. An approach that combined in vitro permeation studies and coarse-gra...

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Bibliographic Details
Main Authors: Ran Wang, Zhimin Wu, Shufang Yang, Shujuan Guo, Xingxing Dai, Yanjiang Qiao, Xinyuan Shi
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:International Journal of Molecular Sciences
Subjects:
penetration enhancement
molecular mechanism
coarse-grained molecular dynamics
menthol
borneol
5-fluorouracil
Online Access:https://www.mdpi.com/1422-0067/18/12/2747

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