Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water

Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione...

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Bibliographic Details
Main Authors: Ke-Hua Zhang, Jing-Jing Xia
Format: Article
Language:English
Published: MDPI AG 2012-05-01
Series:Molecules
Subjects:
acridinedione
polyhydroquinoline
one-pot reaction
water
Online Access:http://www.mdpi.com/1420-3049/17/5/5339
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spelling doaj-412f5389ac8a40d998aeb3eafb3f27fd2020-11-24T23:16:12ZengMDPI AGMolecules1420-30492012-05-011755339534510.3390/molecules17055339Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing WaterKe-Hua ZhangJing-Jing XiaAcridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing  good to excellent yields.http://www.mdpi.com/1420-3049/17/5/5339acridinedionepolyhydroquinolineone-pot reactionwater
collection DOAJ
language English
format Article
sources DOAJ
author Ke-Hua Zhang
Jing-Jing Xia
spellingShingle Ke-Hua Zhang
Jing-Jing Xia
Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
Molecules
acridinedione
polyhydroquinoline
one-pot reaction
water
author_facet Ke-Hua Zhang
Jing-Jing Xia
author_sort Ke-Hua Zhang
title Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_short Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_full Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_fullStr Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_full_unstemmed Synthesis of <em>N</em>-substituted Acridinediones and Polyhydroquinoline Derivatives in Refluxing Water
title_sort synthesis of <em>n</em>-substituted acridinediones and polyhydroquinoline derivatives in refluxing water
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2012-05-01
description Acridinediones were synthesized by the one-pot Hantzsch condensation of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, and aniline/4-methylaniline in refluxing water. This method has then been extended to the four-component reaction of an aromatic aldehyde, 5,5-dimethyl-1,3-cyclohexanedione, ethyl acetoacetate and ammonium acetate for the synthesis of polyhydroquinoline derivatives. This is an environmentally friendly and efficient procedure providing  good to excellent yields.
topic acridinedione
polyhydroquinoline
one-pot reaction
water
url http://www.mdpi.com/1420-3049/17/5/5339
work_keys_str_mv AT kehuazhang synthesisofltemgtnltemgtsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater
AT jingjingxia synthesisofltemgtnltemgtsubstitutedacridinedionesandpolyhydroquinolinederivativesinrefluxingwater
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