Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice

Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole brain readout for adaptive behavior of mice in respon...

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Main Authors: Christopher G. Cover, Andrew J. Kesner, Shehzad Ukani, Elliot A. Stein, Satoshi Ikemoto, Yihong Yang, Hanbing Lu
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01612-x
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spelling doaj-4105e70bb73b4be9906aa9473aea83ec2021-01-17T12:27:04ZengNature Publishing GroupCommunications Biology2399-36422021-01-01411810.1038/s42003-020-01612-xWhole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in miceChristopher G. Cover0Andrew J. Kesner1Shehzad Ukani2Elliot A. Stein3Satoshi Ikemoto4Yihong Yang5Hanbing Lu6Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHBehavioral Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHBehavioral Neuroscience Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHNeuroimaging Research Branch, National Institute on Drug Abuse, Intramural Research Program, NIHCover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole brain readout for adaptive behavior of mice in response to circuit-specific neuromodulation.https://doi.org/10.1038/s42003-020-01612-x
collection DOAJ
language English
format Article
sources DOAJ
author Christopher G. Cover
Andrew J. Kesner
Shehzad Ukani
Elliot A. Stein
Satoshi Ikemoto
Yihong Yang
Hanbing Lu
spellingShingle Christopher G. Cover
Andrew J. Kesner
Shehzad Ukani
Elliot A. Stein
Satoshi Ikemoto
Yihong Yang
Hanbing Lu
Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
Communications Biology
author_facet Christopher G. Cover
Andrew J. Kesner
Shehzad Ukani
Elliot A. Stein
Satoshi Ikemoto
Yihong Yang
Hanbing Lu
author_sort Christopher G. Cover
title Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
title_short Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
title_full Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
title_fullStr Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
title_full_unstemmed Whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
title_sort whole brain dynamics during optogenetic self-stimulation of the medial prefrontal cortex in mice
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole brain readout for adaptive behavior of mice in response to circuit-specific neuromodulation.
url https://doi.org/10.1038/s42003-020-01612-x
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