Genetic inactivation of the Fanconi anemia gene <it>FANCC </it>identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

Genetic inactivation of the Fanconi anemia gene <it>FANCC </it>identified in the hepatocellular carcinoma cell line HuH-7 confers sensitivity towards DNA-interstrand crosslinking agents

<p>Abstract</p> <p>Background</p> <p>Inactivation of the Fanconi anemia (FA) pathway through defects in one of 13 FA genes occurs at low frequency in various solid cancer entities among the general population. As FA pathway inactivation confers a distinct hypersensitivi...

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Bibliographic Details
Main Authors: Bassermann Florian, De Toni Enrico N, Hanenberg Helmut, Thasler Wolfgang E, Meier Daniel, Rizzani Antonia, Ochs Stephanie, Denk Gerald U, Targosz Bianca-Sabrina, Ziesch Andreas, Plinninger Ursula, Neveling Kornelia, Palagyi Andreas, Schäfer Claus, Göke Burkhard, Schindler Detlev, Gallmeier Eike
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/127

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