High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity

High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity

CXCL12 activates CXCR4 and is involved in embryogenesis, hematopoiesis, and angiogenesis. It has pathological roles in HIV-1, WHIM disease, cancer, and autoimmune diseases. An antagonist, AMD3100, is used for the release of CD34+ hematopoietic stem cells from the bone marrow for autologous transplan...

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Bibliographic Details
Main Authors: James W. Murphy, Deepa Rajasekaran, Janie Merkel, Erin Skeens, Camille Keeler, Michael E. Hodsdon, George P. Lisi, Elias Lolis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
chemokine
G protein-coupled receptor
CXCL12
CXCR4
high-throughput screening
fosfosal
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00164/full

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