Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations
A new, simple and sensitive spectrophotometric method for the determination of paracetamol has been developed. The proposed method is based on the reaction of paracetamol with iron(III) and a subsequent reaction with ferricyanide in an hydrochloric acid medium to yield Prussian bluish green coloured...
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| Format: | Article |
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Hindawi Limited
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/875285 |
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doaj-40f83850f5c34c1294f67d888906e7972020-11-25T00:30:08ZengHindawi LimitedE-Journal of Chemistry0973-49452090-98102011-01-018114915210.1155/2011/875285Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical FormulationsP. Nagendra0Department of Chemistry, B E T Academy of Higher Education, Bharathinagara Karnataka-571422, IndiaA new, simple and sensitive spectrophotometric method for the determination of paracetamol has been developed. The proposed method is based on the reaction of paracetamol with iron(III) and a subsequent reaction with ferricyanide in an hydrochloric acid medium to yield Prussian bluish green coloured product with a miximum absorption at 715 nm. There were no interferences observed from the common excipients present in the formulations. The method is successfully employed for the determination of paracetamol in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method.http://dx.doi.org/10.1155/2011/875285 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
P. Nagendra |
| spellingShingle |
P. Nagendra Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations E-Journal of Chemistry |
| author_facet |
P. Nagendra |
| author_sort |
P. Nagendra |
| title |
Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations |
| title_short |
Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations |
| title_full |
Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations |
| title_fullStr |
Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations |
| title_full_unstemmed |
Spectrophotometric Estimation of Paracetamol in Bulk and Pharmaceutical Formulations |
| title_sort |
spectrophotometric estimation of paracetamol in bulk and pharmaceutical formulations |
| publisher |
Hindawi Limited |
| series |
E-Journal of Chemistry |
| issn |
0973-4945 2090-9810 |
| publishDate |
2011-01-01 |
| description |
A new, simple and sensitive spectrophotometric method for the determination of paracetamol has been developed. The proposed method is based on the reaction of paracetamol with iron(III) and a subsequent reaction with ferricyanide in an hydrochloric acid medium to yield Prussian bluish green coloured product with a miximum absorption at 715 nm. There were no interferences observed from the common excipients present in the formulations. The method is successfully employed for the determination of paracetamol in various pharmaceutical preparations and the results have been statistically compared with those obtained by the official method. |
| url |
http://dx.doi.org/10.1155/2011/875285 |
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