Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na+/K+-ATPase

Identification of cisplatin-binding sites on the large cytoplasmic loop of the Na+/K+-ATPase

Cisplatin is the most widely used chemotherapeutic drug for the treatment of various types of cancer; however, its administration brings also numerous side effects. It was demonstrated that cisplatin can inhibit the Na+/K+-ATPase (NKA), which can explain a large part of the adverse effects. In this...

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Bibliographic Details
Main Authors: Jaroslava Šeflová, Petra Čechová, Tereza Štenclová, Marek Šebela, Martin Kubala
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Na+/K+-ATPase
sodium pump
C45 loop
cisplatin
binding site
cysteine mutants
Online Access:http://dx.doi.org/10.1080/14756366.2018.1445735

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