TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation

TAp73 is a structural homolog of the tumor suppressor p53. Here they show that TAp73 is critical for promoting glycolysis as it stimulates the transcriptional expression of liver type of phosphofructokinase-1 (PFKL), which catalyzes the committed step in glycolysis.

Bibliographic Details
Main Authors: Le Li, Lijia Li, Wei Li, Taiqi Chen, Bin Zou, Lina Zhao, Huili Wang, Xueying Wang, Lina Xu, Xiaohui Liu, Dong Wang, Bo Li, Tak W. Mak, Wenjing Du, Xiaolu Yang, Peng Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07127-8

Internet

https://doi.org/10.1038/s41467-018-07127-8

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