Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.

Differential actions of the endocytic collagen receptor uPARAP/Endo180 and the collagenase MMP-2 in bone homeostasis.

A well-coordinated remodeling of uncalcified collagen matrices is a pre-requisite for bone development and homeostasis. Collagen turnover proceeds through different pathways, either involving extracellular reactions exclusively, or being dependent on endocytic processes. Extracellular collagen degra...

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Bibliographic Details
Main Authors: Daniel H Madsen, Henrik J Jürgensen, Signe Ingvarsen, Maria C Melander, Reidar Albrechtsen, Andreas Hald, Kenn Holmbeck, Thomas H Bugge, Niels Behrendt, Lars H Engelholm
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3734290?pdf=render

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