Orphan Three-Finger Toxins Bind at Tissue Factor–Factor VIIa Interface to Inhibit Factor X Activation: Identification of Functional Site by Docking

Orphan Three-Finger Toxins Bind at Tissue Factor–Factor VIIa Interface to Inhibit Factor X Activation: Identification of Functional Site by Docking

Three-finger toxins (3FTxs) contribute to toxicity of venomous snakes belonging to the family Elapidae. Currently, functions of a considerable proportion of 3FTxs are still unknown. Here, we describe the function of orphan group I 3FTxs consisting of four members. We also identified a new member of...

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Bibliographic Details
Main Authors:	Manisha Choudhury, Ryan J. R. McCleary, R. Manjunatha Kini, Devadasan Velmurugan
Format:	Article
Language:	English
Published:	Georg Thieme Verlag KG 2018-07-01
Series:	TH Open
Subjects:	extrinsic tenase complex anticoagulant factor viia–tissue factor complex inhibitor orphan group i toxins
Online Access:	http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1672184

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