Prediction and characterization of liquid-liquid phase separation of minimalistic peptides

Prediction and characterization of liquid-liquid phase separation of minimalistic peptides

Summary: Liquid-liquid phase separation (LLPS) of proteins mediates the assembly of biomolecular condensates involved in physiological and pathological processes. Identifying the minimalistic building blocks and the sequence determinant of protein phase separation is an urgent need but remains chall...

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Bibliographic Details
Main Authors: Yiming Tang, Santu Bera, Yifei Yao, Jiyuan Zeng, Zenghui Lao, Xuewei Dong, Ehud Gazit, Guanghong Wei
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports Physical Science
Subjects:
liquid-liquid phase separation
dipeptide
minimalistic peptide
molecular dynamics simulation
coarse-grained model
Martini forcefield
Online Access:http://www.sciencedirect.com/science/article/pii/S2666386421002940

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