Inflammation-induced Id2 promotes plasticity in regulatory T cells

Inflammation-induced Id2 promotes plasticity in regulatory T cells

Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the trans...

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Main Authors: Sung-Min Hwang, Garima Sharma, Ravi Verma, Seohyun Byun, Dipayan Rudra, Sin-Hyeog Im
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07254-2
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spelling doaj-40cfc8c8e29e492fa639acc455be2eb32021-05-11T09:53:28ZengNature Publishing GroupNature Communications2041-17232018-11-019111310.1038/s41467-018-07254-2Inflammation-induced Id2 promotes plasticity in regulatory T cellsSung-Min Hwang0Garima Sharma1Ravi Verma2Seohyun Byun3Dipayan Rudra4Sin-Hyeog Im5Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Academy of Immunology and Microbiology (AIM), Institute for Basic Science (IBS)Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.https://doi.org/10.1038/s41467-018-07254-2
collection DOAJ
language English
format Article
sources DOAJ
author Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
spellingShingle Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
Inflammation-induced Id2 promotes plasticity in regulatory T cells
Nature Communications
author_facet Sung-Min Hwang
Garima Sharma
Ravi Verma
Seohyun Byun
Dipayan Rudra
Sin-Hyeog Im
author_sort Sung-Min Hwang
title Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_short Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_full Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_fullStr Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_full_unstemmed Inflammation-induced Id2 promotes plasticity in regulatory T cells
title_sort inflammation-induced id2 promotes plasticity in regulatory t cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Regulatory T (Treg) cells may lose the expression of their master transcription factor, Foxp3, and be converted to pro-inflammatory cells. Here the authors show that this lineage plasticity may be mediated by the enhanced expression of another transcription regulator, Id2, which suppresses the transcription of Foxp3 to alter Treg lineage stability.
url https://doi.org/10.1038/s41467-018-07254-2
work_keys_str_mv AT sungminhwang inflammationinducedid2promotesplasticityinregulatorytcells
AT garimasharma inflammationinducedid2promotesplasticityinregulatorytcells
AT raviverma inflammationinducedid2promotesplasticityinregulatorytcells
AT seohyunbyun inflammationinducedid2promotesplasticityinregulatorytcells
AT dipayanrudra inflammationinducedid2promotesplasticityinregulatorytcells
AT sinhyeogim inflammationinducedid2promotesplasticityinregulatorytcells
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