Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy

Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy

Reactive oxygen species (ROS) can promote or inhibit tumorigenesis. In mesothelioma, asbestos exposure to serous membranes induces ROS through iron content and chronic inflammation, and ROS promote cell survival signaling in mesothelioma. Moreover, a current chemotherapy regimen for mesothelioma con...

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Bibliographic Details
Main Authors: Derek B. Oien, Tamás Garay, Sarah Eckstein, Jeremy Chien
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
AXL
reactive oxygen species
cisplatin
pemetrexed
mesothelioma
BGB324
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00970/full

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