Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents

Versatility of 7-Substituted Coumarin Molecules as Antimycobacterial Agents, Neuronal Enzyme Inhibitors and Neuroprotective Agents

A medium-throughput screen using Mycobacterium tuberculosis H37Rv was employed to screen an in-house library of structurally diverse compounds for antimycobacterial activity. In this initial screen, eleven 7-substituted coumarin derivatives with confirmed monoamine oxidase-B and cholinesterase inhib...

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Bibliographic Details
Main Authors: Erika Kapp, Hanri Visser, Samantha L. Sampson, Sarel F. Malan, Elizabeth M. Streicher, Germaine B. Foka, Digby F. Warner, Sylvester I. Omoruyi, Adaze B. Enogieru, Okobi E. Ekpo, Frank T. Zindo, Jacques Joubert
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Molecules
Subjects:
coumarin
Mycobacterium tuberculosis
cholinesterase inhibitor
monoamine oxidase B inhibitor
structure-activity relationship
albumin binding
neuroprotection
Online Access:https://www.mdpi.com/1420-3049/22/10/1644

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