Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia

Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia

Abstract The magneto-thermal effect, which represents the conversion of magnetostatic energy to heat from magnetic materials, has been spotlighted for potential therapeutic usage in hyperthermia treatments. However, the realization of its potential has been challenged owing to the limited heating fr...

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Main Authors: Jae-Hyeok Lee, Bosung Kim, Yongsub Kim, Sang-Koog Kim
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-84424-1
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spelling doaj-40c6bedc7bad423a8ae18c389b3ad82d2021-03-11T12:24:24ZengNature Publishing GroupScientific Reports2045-23222021-03-011111910.1038/s41598-021-84424-1Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermiaJae-Hyeok Lee0Bosung Kim1Yongsub Kim2Sang-Koog Kim3National Creative Research Initiative Center for Spin Dynamics and Spin-Wave Devices, Nanospinics Laboratory, Research Institute of Advanced Materials, Department of Materials Science and Engineering, Seoul National UniversityNational Creative Research Initiative Center for Spin Dynamics and Spin-Wave Devices, Nanospinics Laboratory, Research Institute of Advanced Materials, Department of Materials Science and Engineering, Seoul National UniversityNational Creative Research Initiative Center for Spin Dynamics and Spin-Wave Devices, Nanospinics Laboratory, Research Institute of Advanced Materials, Department of Materials Science and Engineering, Seoul National UniversityNational Creative Research Initiative Center for Spin Dynamics and Spin-Wave Devices, Nanospinics Laboratory, Research Institute of Advanced Materials, Department of Materials Science and Engineering, Seoul National UniversityAbstract The magneto-thermal effect, which represents the conversion of magnetostatic energy to heat from magnetic materials, has been spotlighted for potential therapeutic usage in hyperthermia treatments. However, the realization of its potential has been challenged owing to the limited heating from the magnetic nanoparticles. Here, we explored a new-concept of magneto-thermal modality marked by low-power-driven, fast resonant spin-excitation followed by consequent energy dissipation, which concept has yet to be realized for current hyperthermia applications. We investigated the effect of spin resonance-mediated heat dissipation using superparamagnetic Fe3O4 nanoparticles and achieved an extraordinary initial temperature increment rate of more than 150 K/s, which is a significant increase in comparison to that for the conventional magnetic heat induction of nanoparticles. This work would offer highly efficient heat generation and precision wireless controllability for realization of magnetic-hyperthermia-based medical treatment.https://doi.org/10.1038/s41598-021-84424-1
collection DOAJ
language English
format Article
sources DOAJ
author Jae-Hyeok Lee
Bosung Kim
Yongsub Kim
Sang-Koog Kim
spellingShingle Jae-Hyeok Lee
Bosung Kim
Yongsub Kim
Sang-Koog Kim
Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
Scientific Reports
author_facet Jae-Hyeok Lee
Bosung Kim
Yongsub Kim
Sang-Koog Kim
author_sort Jae-Hyeok Lee
title Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
title_short Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
title_full Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
title_fullStr Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
title_full_unstemmed Ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
title_sort ultra-high rate of temperature increment from superparamagnetic nanoparticles for highly efficient hyperthermia
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2021-03-01
description Abstract The magneto-thermal effect, which represents the conversion of magnetostatic energy to heat from magnetic materials, has been spotlighted for potential therapeutic usage in hyperthermia treatments. However, the realization of its potential has been challenged owing to the limited heating from the magnetic nanoparticles. Here, we explored a new-concept of magneto-thermal modality marked by low-power-driven, fast resonant spin-excitation followed by consequent energy dissipation, which concept has yet to be realized for current hyperthermia applications. We investigated the effect of spin resonance-mediated heat dissipation using superparamagnetic Fe3O4 nanoparticles and achieved an extraordinary initial temperature increment rate of more than 150 K/s, which is a significant increase in comparison to that for the conventional magnetic heat induction of nanoparticles. This work would offer highly efficient heat generation and precision wireless controllability for realization of magnetic-hyperthermia-based medical treatment.
url https://doi.org/10.1038/s41598-021-84424-1
work_keys_str_mv AT jaehyeoklee ultrahighrateoftemperatureincrementfromsuperparamagneticnanoparticlesforhighlyefficienthyperthermia
AT bosungkim ultrahighrateoftemperatureincrementfromsuperparamagneticnanoparticlesforhighlyefficienthyperthermia
AT yongsubkim ultrahighrateoftemperatureincrementfromsuperparamagneticnanoparticlesforhighlyefficienthyperthermia
AT sangkoogkim ultrahighrateoftemperatureincrementfromsuperparamagneticnanoparticlesforhighlyefficienthyperthermia
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