Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

Deletion of sorting nexin 27 suppresses proliferation in highly aggressive breast cancer MDA-MB-231 cells in vitro and in vivo

Abstract Background Sorting Nexin 27 (SNX27) belongs to a family of sortin nexins and possesses a unique binding domain at the C-terminus which mediates protein-protein interaction in intracellular trafficking, membrane remodeling, organelle motility, and tight junctions. However, its role in cancer...

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Bibliographic Details
Main Authors: Jilei Zhang, Kendy Li, Yongguo Zhang, Rong Lu, Shaoping Wu, Jingrong Tang, Yinglin Xia, Jun Sun
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Epithelial-mesenchymal transition
Cell adhesion
Cell junctions
Breast cancer
Sorting nexin 27
Proliferation
Online Access:http://link.springer.com/article/10.1186/s12885-019-5769-z

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