A cytogenetic study of couples with repeated spontaneous abortions

• Main Authors: Niroumanesh Shirin, Mehdipour Parvin, Farajpour Ali, Darvish Soodabeh
• Format: Article
• Language: English
• Published: King Faisal Specialist Hospital and Research Centre 2011-01-01
• Series: Annals of Saudi Medicine
• Online Access: http://www.saudiannals.net/article.asp?issn=0256-4947;year=2011;volume=31;issue=1;spage=77;epage=79;aulast=Niroumanesh

<b>Background</b> <b>and Objective :</b> The frequency of chromosomal aberrations in Iran is not definitely known. This study determined the frequency of chromosomal aberrations in a series of couples with two or more spontaneous abortions and compared the findings with that reported from other countries. <b>Methods</b> : This was a descriptive study conducted on 100 couples with recurrent abortions. Both partners were karyotyped as part of the primary investigation. Other probable causes of abortion were also investigated. <b>Results</b> : Chromosomal aberrations were found in 8 (8&#x0025;) of the females and 5 (5&#x0025;) of the males. The prevalence of chromosomal abnormalities was as follows: 4 (30.8&#x0025;) balanced reciprocal translocations, 3 (23&#x0025;) Robertsonian translocations, 3 (23&#x0025;) pericentric inversions, 1 (7.7&#x0025;) paracentric inversion, 1 (7.7&#x0025;) chromosomal marker, and 1 (7.7&#x0025;) polymorphism 9qh&#x002B;. <b>Conclusions</b> : The pattern of chromosomal aberrations was similar to that reported in other studies, but the prevalence of chromosomal aberrations was higher.