Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

Rationale: Gestational cigarette smoke (CS) impairs lung angiogenesis and alveolarization, promoting transgenerational development of asthma and bronchopulmonary dysplasia (BPD). Hydrogen sulfide (H2S), a proangiogenic, pro-alveolarization, and anti-asthmatic gasotransmitter is synthesized by cystat...

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Bibliographic Details
Main Authors: Shashi P. Singh, Dinesh Devadoss, Marko Manevski, Aryaz Sheybani, Teodora Ivanciuc, Vernat Exil, Hemant Agarwal, Veena Raizada, Roberto P. Garofalo, Hitendra S. Chand, Mohan L. Sopori
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
gestational cigarette smoke
H2S biogenesis
human placenta
lungs
transgenerational effect
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01628/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01628/full

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