Multifunctional TPP-PEG-biotin self-assembled nanoparticle drug delivery-based combination therapeutic approach for co-targeting of GRP78 and lysosome

Multifunctional TPP-PEG-biotin self-assembled nanoparticle drug delivery-based combination therapeutic approach for co-targeting of GRP78 and lysosome

Abstract Background In this study, a multifunctional tetraphenylporphyrin (TPP) conjugated polyethylene glycol with biotin (TPP-PEG-biotin) as a photo-dynamic therapy (PDT) material encapsulating a ruthenium complex 1 (Ru-1) was fabricated as self-assembled nanoparticle (Ru-1@TPP-PEG-biotin SAN) to...

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Bibliographic Details
Main Authors: Baskaran Purushothaman, Jeongmin Lee, Sera Hong, Joon Myong Song
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Journal of Nanobiotechnology
Subjects:
TPP-PEG-biotin self-assembly
Combination therapy
Autophagy
GRP78
Co-targeting
Online Access:http://link.springer.com/article/10.1186/s12951-020-00661-y

Internet

http://link.springer.com/article/10.1186/s12951-020-00661-y

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