OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth

OKN-007 Increases temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth

Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug resistance. We have assessed a novel nitrone-based agent, OKN-007, and found it to be effective in decreasing tumor volumes and increasing sur...

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Bibliographic Details
Main Authors: Rheal A. Towner, Nataliya Smith, Debra Saunders, Chase A. Brown, Xue Cai, Jadith Ziegler, Samantha Mallory, Mikhail G. Dozmorov, Patricia Coutinho De Souza, Graham Wiley, Kyeongsoon Kim, Shinwook Kang, Doo-Sik Kong, Young-Tae Kim, Kar-Ming Fung, Jonathan D. Wren, James Battiste
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318303954

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http://www.sciencedirect.com/science/article/pii/S1936523318303954

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