Assessing the Relationship between <i>Helicobacter pylori</i> and Chronic Kidney Disease

• Main Authors: Koichi Hata, Teruhide Koyama, Etsuko Ozaki, Nagato Kuriyama, Shigeto Mizuno, Daisuke Matsui, Isao Watanabe, Ritei Uehara, Yoshiyuki Watanabe
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Healthcare
• Subjects: atrophic gastritis; chronic kidney disease; <i>Helicobacter pylori</i>; inter-organ interactions
• Online Access: https://www.mdpi.com/2227-9032/9/2/162

The relationship between <i>Helicobacter pylori</i> infection and/or gastric disorders and chronic kidney disease (CKD) has not been elucidated. We investigated the relationship between <i>Helicobacter pylori</i> and/or atrophic gastritis (AG) and chronic kidney disease. In total, 3560 participants (1127 men and 2433 women) were eligible for this cross-sectional study. We divided participants into four study groups: with/without <i>Helicobacter pylori</i> infection and with/without AG. The HP (+) AG (−) group demonstrated a significant association with CKD compared with the HP (−) AG (−) group (adjusted odds ratio, 1.443; 95% confidence interval, 1.047–1.989). In contrast, the HP (+) AG (+) group showed significantly lower adjusted odds of CKD than the HP (−) AG (−) group (adjusted odds ratio, 0.608; 95% confidence interval, 0.402–0.920). <i>H. pylori</i> infection without AG might be associated with CKD in these participants. Conversely, the HP (+) AG (+) group had lower odds of CKD. Uncovering an association between gastric and renal conditions could lead to development of new treatment strategies.