Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes

Human Retrotransposon Insertion Polymorphisms Are Associated with Health and Disease via Gene Regulatory Phenotypes

The human genome hosts several active families of transposable elements (TEs), including the Alu, LINE-1, and SVA retrotransposons that are mobilized via reverse transcription of RNA intermediates. We evaluated how insertion polymorphisms generated by human retrotransposon activity may be related to...

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Bibliographic Details
Main Authors: Lu Wang, Emily T. Norris, I. K. Jordan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Microbiology
Subjects:
transposable elements
retrotransposons
Alu
L1
SVA
gene expression
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01418/full

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