P7.05 ASSOCIATION BETWEEN RENAL FUNCTION AND ARTERIAL STIFFNESS IN NEVER-TREATED HYPERTENSIVES

• Main Authors: D. Terentes-Printzios, C. Vlachopoulos, N. Ioakeimidis, K. Aznaouridis, K. Baou, P. Pietri, N. Alexopoulos, I. Dima, A. Siama, C. Stefanadis
• Format: Article
• Language: English
• Published: Atlantis Press 2009-12-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125927270/view

Introduction: Hypertension and renal dysfunction are associated with increased arterial stiffness. Arterial stiffness is a marker of cardiovascular disease and predictor of cardiovascular risk. We assessed the relationship between renal function and arterial stiffness in never-treated hypertensives. Methods: We enrolled 388 consecutive essential hypertensives (mean age 52±12 years), who had no established cardiovascular disease. Arterial elastic properties were evaluated with carotid-femoral pulse wave velocity (PWV). Renal function was evaluated with blood creatinine and estimated glomerular filtration rate, measured by the simplified Modification of Diet in Renal Disease (MDRD) formula and the Cockcroft-Gault formula. Results: In multivariable regression analysis PWV significantly correlated with blood creatinine levels (p<0.05, adjusted R2 of model=0.224) and estimated GFR by the Cockroft-Gault formula (p=0.05, adjusted R2 of model=0.222), as well as by the MDRD formula (p<0.05, adjusted R2 of model=0.223). (Figure) The abovementioned correlations were independent of age, sex, body-mass index and mean blood pressure. Conclusion: This is the first study in never-treated hypertensives that shows a weak but significant relationship between the degree of GFR loss and arterial stiffness, even in individuals with GFR values within the normal renal function range.