Impact of Host, Lifestyle and Environmental Factors in the Pathogenesis of MPN

Philadelphia-negative myeloproliferative neoplasms (MPNs) occur when there is over-production of myeloid cells stemming from hematopoietic stem cells with constitutive activation of JAK/STAT signaling, with <i>JAK2<sup>V617F</sup></i> being the most commonly occurring somatic...

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Bibliographic Details
Main Authors: Gajalakshmi Ramanathan, Brianna M Hoover, Angela G Fleischman
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/12/8/2038