Early diagnosis of sub-clinical stage of diabetic retinopathy

• Main Authors: Xing-Hui Xu, Wu-Feng Zhang
• Format: Article
• Language: English
• Published: Press of International Journal of Ophthalmology (IJO PRESS) 2014-12-01
• Series: Guoji Yanke Zazhi
• Subjects: diabetic retinopathy; multifocal retina electroretinogram; contrast sensitivity; central retinal artery
• Online Access: http://ies.ijo.cn/cn_publish/2014/12/201412029.pdf

AIM: To evaluate the early diagnosis of sub-clinic stage of diabetic retinopathy.<p>METHODS: This was cross sectional study,multifocal retina electroretinogram(mf-ERG), contrast sensitivity(CS)and central retinal artery color Doppler examination were recorded from 30 cases(30 eyes)matched control subjects, 35 cases(35 eyes)with type 2 diabetes mellitus(DM)without diabetic retinopathy(NDR)and 38 cases(38 eyes)with non-prolifera tive diabetic retinopathy(NPDR). One-way ANOVA and SNK-<i>q</i> test were used for data analysis.<p>RESULTS: P1 response density of NDR patients were found decrease, N1 implicit time were delayed. Which were related with the degree of retinopathy(<i>P</i><0.05); CS of NDR patients were found significant in middle and high frequency(<i>P</i><0.05), NPDR patients were found significant in full frequency(<i>P</i><0.05); Central retinal artery(CRA)blood flow in the control groups and NDR groups were not found statistically significant(<i>P</i>>0.05), The differences between normal group, NDR group and NPDR group were found statistically significant(<i>P</i><0.05).<p>CONCLUSION: mf-ERG and CS are sensitive indexes for early evaluation of visual function in patients with diabetes mellitus, with development of the disease, CRA blood flow also appears to decline.