Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice

Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice

The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the...

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Main Authors: Yasutaka Takinishi, Masako Okazaki, Katsuji Oguchi
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319322200
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spelling doaj-402fb11d2f3844f79ce9b6ff43a412c02020-11-25T02:20:56ZengElsevierJournal of Pharmacological Sciences1347-86132005-01-019819498Effect of L-NAME on the Synthesis of Plasma Fibrinogen in MiceYasutaka Takinishi0Masako Okazaki1Katsuji Oguchi2Department of Pharmacology, Showa University School of Medicine, Tokyo 142-8555, JapanDepartment of Pharmacology, Showa University School of Medicine, Tokyo 142-8555, Japan; Corresponding author. FAX: +81-3-3787-4790 E-mail: okazakim@med.showa-u.ac.jpDepartment of Pharmacology, Showa University School of Medicine, Tokyo 142-8555, JapanThe effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the α- and β-chains of fibrinogen, whereas plasma NO2− level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase. Keywords:: fibrinogen, NG-nitro-L-arginine-methyl ester, mRNAhttp://www.sciencedirect.com/science/article/pii/S1347861319322200
collection DOAJ
language English
format Article
sources DOAJ
author Yasutaka Takinishi
Masako Okazaki
Katsuji Oguchi
spellingShingle Yasutaka Takinishi
Masako Okazaki
Katsuji Oguchi
Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
Journal of Pharmacological Sciences
author_facet Yasutaka Takinishi
Masako Okazaki
Katsuji Oguchi
author_sort Yasutaka Takinishi
title Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
title_short Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
title_full Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
title_fullStr Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
title_full_unstemmed Effect of L-NAME on the Synthesis of Plasma Fibrinogen in Mice
title_sort effect of l-name on the synthesis of plasma fibrinogen in mice
publisher Elsevier
series Journal of Pharmacological Sciences
issn 1347-8613
publishDate 2005-01-01
description The effect of nitric oxide (NO) on plasma fibrinogen was investigated by treating mice with oral NG-nitro-L-arginine-methyl ester (L-NAME), a non-selective NO synthase (NOS) inhibitor. Treatment with L-NAME significantly increased the concentration of plasma fibrinogen and hepatic expression of the α- and β-chains of fibrinogen, whereas plasma NO2− level and hepatic expression of endothelial NOS (eNOS) mRNA were significantly decreased. These results suggest that L-NAME treatment can increase plasma fibrinogen levels via an increase in expression of fibrinogen mRNA in the liver, and NO may be involved in plasma fibrinogen increase. Keywords:: fibrinogen, NG-nitro-L-arginine-methyl ester, mRNA
url http://www.sciencedirect.com/science/article/pii/S1347861319322200
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AT katsujioguchi effectoflnameonthesynthesisofplasmafibrinogeninmice
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