NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief

NF-KappaB Pathway Is Involved in Bone Marrow Stromal Cell-Produced Pain Relief

Bone marrow stromal cells (BMSCs) produce long-lasting attenuation of pain hypersensitivity. This effect involves BMSC’s ability to interact with the immune system and activation of the endogenous opioid receptors in the pain modulatory circuitry. The nuclear factor kappa B (NF-κB) protein complex i...

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Bibliographic Details
Main Authors: Wei Guo, Satoshi Imai, Jia-Le Yang, Shiping Zou, Huijuan Li, Huakun Xu, Kamal D. Moudgil, Ronald Dubner, Feng Wei, Ke Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Integrative Neuroscience
Subjects:
orofacial pain
tendon ligation
mesenchymal stromal cells
BAY 11-7082
chemokine
rostral ventromedial medulla
Online Access:https://www.frontiersin.org/article/10.3389/fnint.2018.00049/full

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