A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases, including Rab8A and Rab10. We show here that LRRK2 kinase interferes with primary cilia formation in cultured cells, human LRRK2 G2019S iPS cells and in the cortex of LRRK2 R1441C mice. Rab10 phosphorylation strengthens...

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Bibliographic Details
Main Authors: Herschel S Dhekne, Izumi Yanatori, Rachel C Gomez, Francesca Tonelli, Federico Diez, Birgitt Schüle, Martin Steger, Dario R Alessi, Suzanne R Pfeffer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-11-01
Series:eLife
Subjects:
Parkinson's Disease
LRRK2
Rab GTPases
primary cilia
Online Access:https://elifesciences.org/articles/40202

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