Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease

Chronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that...

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Main Authors: J Chen, C-M Chai, W Dalu, L Shen, F Fromowitz, C Compton, MV Viola
Format: Article
Language:English
Published: Hindawi Limited 1990-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/1990/329374
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spelling doaj-4014e214d02f4c06a98e25fe08c85feb2020-11-24T22:30:43ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001990-01-014738438910.1155/1990/329374Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel DiseaseJ Chen0C-M Chai1W Dalu2L Shen3F Fromowitz4C Compton5MV Viola6Departments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USAChronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that the frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid substitutions, were similar in sporadic colon cancers, cancers associated with ulcerative colitis in the United States, and colon cancers found in patients with schistosomal colitis in Jiangsu province in China. Further, activating mutations of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic ulcerative colitis. The latter finding indicates that some dysplasias are clonal proliferative lesions with genetic characteristics associated with invasive cancer.http://dx.doi.org/10.1155/1990/329374
collection DOAJ
language English
format Article
sources DOAJ
author J Chen
C-M Chai
W Dalu
L Shen
F Fromowitz
C Compton
MV Viola
spellingShingle J Chen
C-M Chai
W Dalu
L Shen
F Fromowitz
C Compton
MV Viola
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
Canadian Journal of Gastroenterology
author_facet J Chen
C-M Chai
W Dalu
L Shen
F Fromowitz
C Compton
MV Viola
author_sort J Chen
title Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
title_short Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
title_full Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
title_fullStr Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
title_full_unstemmed Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
title_sort oncogene mutations in cancer and dysplasia associated with inflammatory bowel disease
publisher Hindawi Limited
series Canadian Journal of Gastroenterology
issn 0835-7900
publishDate 1990-01-01
description Chronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that the frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid substitutions, were similar in sporadic colon cancers, cancers associated with ulcerative colitis in the United States, and colon cancers found in patients with schistosomal colitis in Jiangsu province in China. Further, activating mutations of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic ulcerative colitis. The latter finding indicates that some dysplasias are clonal proliferative lesions with genetic characteristics associated with invasive cancer.
url http://dx.doi.org/10.1155/1990/329374
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AT wdalu oncogenemutationsincanceranddysplasiaassociatedwithinflammatoryboweldisease
AT lshen oncogenemutationsincanceranddysplasiaassociatedwithinflammatoryboweldisease
AT ffromowitz oncogenemutationsincanceranddysplasiaassociatedwithinflammatoryboweldisease
AT ccompton oncogenemutationsincanceranddysplasiaassociatedwithinflammatoryboweldisease
AT mvviola oncogenemutationsincanceranddysplasiaassociatedwithinflammatoryboweldisease
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