Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease
Chronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that...
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doaj-4014e214d02f4c06a98e25fe08c85feb2020-11-24T22:30:43ZengHindawi LimitedCanadian Journal of Gastroenterology0835-79001990-01-014738438910.1155/1990/329374Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel DiseaseJ Chen0C-M Chai1W Dalu2L Shen3F Fromowitz4C Compton5MV Viola6Departments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USADepartments of Medicine and Pathology, State University of New York at Stony Brook, Stony Brook, New York, USAChronic inflammatory bowel disease (IBO) predisposes affected individuals to the development of invasive colon cancer. Increased cancer risk has been seen in ulcerative colitis and Crohn's disease in Western societies as well as in schistosomal colitis in China. In this study it was found that the frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid substitutions, were similar in sporadic colon cancers, cancers associated with ulcerative colitis in the United States, and colon cancers found in patients with schistosomal colitis in Jiangsu province in China. Further, activating mutations of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic ulcerative colitis. The latter finding indicates that some dysplasias are clonal proliferative lesions with genetic characteristics associated with invasive cancer.http://dx.doi.org/10.1155/1990/329374 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
J Chen C-M Chai W Dalu L Shen F Fromowitz C Compton MV Viola |
spellingShingle |
J Chen C-M Chai W Dalu L Shen F Fromowitz C Compton MV Viola Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease Canadian Journal of Gastroenterology |
author_facet |
J Chen C-M Chai W Dalu L Shen F Fromowitz C Compton MV Viola |
author_sort |
J Chen |
title |
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease |
title_short |
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease |
title_full |
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease |
title_fullStr |
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease |
title_full_unstemmed |
Oncogene Mutations in Cancer and Dysplasia Associated with Inflammatory Bowel Disease |
title_sort |
oncogene mutations in cancer and dysplasia associated with inflammatory bowel disease |
publisher |
Hindawi Limited |
series |
Canadian Journal of Gastroenterology |
issn |
0835-7900 |
publishDate |
1990-01-01 |
description |
Chronic inflammatory bowel disease (IBO) predisposes affected
individuals to the development of invasive colon cancer. Increased cancer risk
has been seen in ulcerative colitis and Crohn's disease in Western societies as
well as in schistosomal colitis in China. In this study it was found that the
frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid
substitutions, were similar in sporadic colon cancers, cancers associated with
ulcerative colitis in the United States, and colon cancers found in patients with
schistosomal colitis in Jiangsu province in China. Further, activating mutations
of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic
ulcerative colitis. The latter finding indicates that some dysplasias are clonal
proliferative lesions with genetic characteristics associated with invasive cancer. |
url |
http://dx.doi.org/10.1155/1990/329374 |
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