| Summary: | Chronic inflammatory bowel disease (IBO) predisposes affected
individuals to the development of invasive colon cancer. Increased cancer risk
has been seen in ulcerative colitis and Crohn's disease in Western societies as
well as in schistosomal colitis in China. In this study it was found that the
frequency of the 12th codon of c-Ki-ras, as well as the specific amino acid
substitutions, were similar in sporadic colon cancers, cancers associated with
ulcerative colitis in the United States, and colon cancers found in patients with
schistosomal colitis in Jiangsu province in China. Further, activating mutations
of codon 12 of e-Ki-ras were found in high grade dysplastic lesions in chronic
ulcerative colitis. The latter finding indicates that some dysplasias are clonal
proliferative lesions with genetic characteristics associated with invasive cancer.
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