Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma

Post-treatment de-phosphorylation of p53 correlates with dasatinib responsiveness in malignant melanoma

Abstract Background Dasatinib (Sprycel) was developed as a tyrosine kinase inhibitor targeting Bcr-Abl and the family of Src kinases. Dasatinib is commonly used for the treatment of acute lymphoblastic and chronic myelogenous leukemia. Previous clinical studies in melanoma returned inconclusive resu...

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Bibliographic Details
Main Authors: Josip Skoko, Jan Rožanc, Emilie M. Charles, Leonidas G. Alexopoulos, Markus Rehm
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cell Biology
Subjects:
Melanoma
Dasatinib
Dacarbazine
Proliferation
Cell death
Online Access:http://link.springer.com/article/10.1186/s12860-018-0180-1

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