Knock down of HIF-1α in glioma cells reduces migration <it>in vitro </it>and invasion <it>in vivo </it>and impairs their ability to form tumor spheres

Knock down of HIF-1α in glioma cells reduces migration <it>in vitro </it>and invasion <it>in vivo </it>and impairs their ability to form tumor spheres

<p>Abstract</p> <p>Background</p> <p>Glioblastoma (GBM) is the most common and malignant primary intracranial human neoplasm. GBMs are characterized by the presence of extensive areas of necrosis and hypoxia. Hypoxia and its master regulator, hypoxia inducible factor 1...

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Bibliographic Details
Main Authors: Esencay Mine, Zavadil Jiri, Méndez Olga, Lukyanov Yevgeniy, Santovasi Daniel, Wang Shu-Chi, Newcomb Elizabeth W, Zagzag David
Format: Article
Language:English
Published: BMC 2010-06-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/9/1/133

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