The utility of mitochondrial and Y chromosome phylogenetic data to improve correction for population stratification

The utility of mitochondrial and Y chromosome phylogenetic data to improve correction for population stratification

Genome-wide association (GWA) studies have become a standard approach for discovering and validating genomic polymorphisms putatively associated with phenotypes of interest. Accounting for population structure in GWA studies is critical to attain unbiased parameter measurements and control Type I er...

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Bibliographic Details
Main Authors: Robert eMakowsky, Qi eYan, Howard W Wiener, Michael eSandel, Brahim eAissani, Hemant K Tiwari, Sadeep eShrestha
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Genetics
Subjects:
Mitochondria
Y Chromosome
phylogeny
PCA
population sub-structure
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00301/full

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