Synthesis, Urease Inhibition and Molecular Modelling Studies of Novel Derivatives of the Naturally Occurring β-Amyrenone

Synthesis, Urease Inhibition and Molecular Modelling Studies of Novel Derivatives of the Naturally Occurring β-Amyrenone

Abstract Urease enzyme (UE) has been reported to be a potent virulence factor for Helicobacter pylori (HP) bacteria indicated to be responsible for various gastrointestinal diseases. Therefore, the spread of HP, currently regarded by the World Health Organization as a class 1 carcinogen, could be be...

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Bibliographic Details
Main Authors: Jean J. K. Bankeu, Hira Sattar, Yannick S. F. Fongang, Syeda W. Muhammadi, Conrad V. Simoben, Fidele Ntie-Kang, Guy R. T. Feuya, Marthe A. T. Tchuenmogne, Mehreen Lateef, Bruno N. Lenta, Muhammad S. Ali, Augustin S. Ngouela
Format: Article
Language:English
Published: SpringerOpen 2018-11-01
Series:Natural Products and Bioprospecting
Subjects:
Helicobacter pylori
Urease inhibition
Docking
Olean-12-en-3-one derivatives
Online Access:http://link.springer.com/article/10.1007/s13659-018-0193-7

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