Effects of hemoperfusion combined with hemodialysis on target organ damage in patients with acute paraquat poisoning
Objective: To investigate the effects of hemoperfusion combined with hemodialysis on target organ damage in patients with acute paraquat poisoning. Methods: A total of 42 patients with acute paraquat poisoning who were admitted and treated in our hospital between December 2013 and October 2017 we...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Editorial Board of Journal of Hainan Medical University
2018-09-01
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| Series: | Journal of Hainan Medical University |
| Subjects: | |
| Online Access: | http://www.hnykdxxb.com/PDF/201819/08.pdf |
| Summary: | Objective: To investigate the effects of hemoperfusion combined with hemodialysis on target
organ damage in patients with acute paraquat poisoning. Methods: A total of 42 patients with
acute paraquat poisoning who were admitted and treated in our hospital between December
2013 and October 2017 were selected as the research subjects, and their therapies were
reviewed and used to divide them into the control group (n=20) who received hemoperfusion
alone and the combined treatment group (n=22) who received hemoperfusion combined with
hemodialysis. The differences in the levels of liver and kidney function indexes in peripheral
blood as well as lung function indexes in arterial blood were compared between the two groups
of patients immediately after admission, after 1 d of treatment and after 3 d of treatment.
Results: Immediately after admission, the differences in the levels of liver and kidney
function indexes in peripheral blood as well as lung function indexes in arterial blood were not
statistically significant between the two groups. After 1d of treatment and after 3 d of treatment,
kidney function indexes Scr, BUN and β2-MG levels in peripheral blood of combined treatment
group were lower than those of control group at corresponding time points respectively; liver
function indexes ALT, AST, TB and ALP levels in peripheral blood were lower than those
of control group at corresponding time points respectively; lung function indexes PaO2, BE
and PCO3- levels in arterial blood were higher than those of control group at corresponding
time points respectively whereas PaCO2 levels were lower than those of control group at
corresponding time points respectively. Conclusion: Compared with hemoperfusion alone,
hemoperfusion combined with hemodialysis is more advantageous in protecting the functions of
liver, kidney, lungs and other target organs of patients with acute paraquat poisoning. |
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| ISSN: | 1007-1237 1007-1237 |