Influenza evolution navigates stability valleys

By reconstructing how an influenza protein collected in 1968 might have evolved into one collected in 2007, researchers have obtained new insights into the interactions between genetic mutations.

Bibliographic Details
Main Authors: Mary M Rorick, Mercedes Pascual
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/00842
id doaj-3feaaaf7b3654eb6b8a8b188ad136e10
record_format Article
spelling doaj-3feaaaf7b3654eb6b8a8b188ad136e102021-05-04T22:26:34ZengeLife Sciences Publications LtdeLife2050-084X2013-05-01210.7554/eLife.00842Influenza evolution navigates stability valleysMary M Rorick0Mercedes Pascual1Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, United StatesDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, United StatesBy reconstructing how an influenza protein collected in 1968 might have evolved into one collected in 2007, researchers have obtained new insights into the interactions between genetic mutations.https://elifesciences.org/articles/00842epistasisprotein evolutionprotein instabilityinfluenza
collection DOAJ
language English
format Article
sources DOAJ
author Mary M Rorick
Mercedes Pascual
spellingShingle Mary M Rorick
Mercedes Pascual
Influenza evolution navigates stability valleys
eLife
epistasis
protein evolution
protein instability
influenza
author_facet Mary M Rorick
Mercedes Pascual
author_sort Mary M Rorick
title Influenza evolution navigates stability valleys
title_short Influenza evolution navigates stability valleys
title_full Influenza evolution navigates stability valleys
title_fullStr Influenza evolution navigates stability valleys
title_full_unstemmed Influenza evolution navigates stability valleys
title_sort influenza evolution navigates stability valleys
publisher eLife Sciences Publications Ltd
series eLife
issn 2050-084X
publishDate 2013-05-01
description By reconstructing how an influenza protein collected in 1968 might have evolved into one collected in 2007, researchers have obtained new insights into the interactions between genetic mutations.
topic epistasis
protein evolution
protein instability
influenza
url https://elifesciences.org/articles/00842
work_keys_str_mv AT marymrorick influenzaevolutionnavigatesstabilityvalleys
AT mercedespascual influenzaevolutionnavigatesstabilityvalleys
_version_ 1721477289088122880