Evaluation of Atorvastatin Safety on Liver Function Tests, a Prospective Study

• Main Authors: Ramin Talaie, Mohammad Bagher Motevallian
• Format: Article
• Language: English
• Published: Shahid Beheshti University of Medical Sciences 2015-07-01
• Series: Novelty in Biomedicine
• Subjects: Keywords: HMGG-COA reductase, hepatotoxicity, statins, atorvastatin
• Online Access: http://journals.sbmu.ac.ir/index.php/nbm/article/view/7657

<h2>Background: Although lipid lowering agents as statins are used frequently in hyperlipidemic patients as well as patients with cardiac disease, they could have major hepatic side effects, the aim of this study is to evaluate the safety of statins mainly atorvastatin on liver as estimated by liver aminotransferase assay.</h2><p><strong>M</strong><strong>aterials and Methods: </strong>Patients with indication of atorvastatin were included the study. As a before and after study all the patients underwent serum level measurement of aminotransferases at the beginning and after three month of taking the drug.</p><p><strong>R</strong><strong>es</strong><strong>ults and Conclusion: </strong>HMG-COA reductase as atorvastatin should be safe in different doses 20,40 and 80 mg in patient with hyperlipidemia with and without cardiac disease without significant hepatotoxicity.</p>